Table 5. Log-transformed, covariate adjusted CSF biomarker data between FH groups, within diagnosis.

	FH−	FH+	FH+ subgroups
			FHp	FHm
Diagnosis at baseline
ND	n = 61	n =51	n =14	n = 34
Log-transformed total tau, pg/mL	1.79 (0.17)	1.82 (0.17)	1.82 (0.18)	1.80 (0.15)
Log-transformed Aβ, pg/mL	2.31 (0.13)	2.28 (0.13)	2.30 (0.13)	2.28 (0.13)
Log-transformed tau/Aβ ratio	−0.51 (0.24)	−0.45 (0.24)	−0.48 (0.24)	−0.48 (0.21)
MCI	n = 96	n =95	n =21	n = 62
Log-transformed total tau, pg/mL	1.93 (0.21)	2.0 (0.22)	1.90 (0.19)	1.99 (0.24)°
Log-transformed Aβ, pg/mL	2.21 (0.14)	2.16 (0.13)◦	2.22 (0.14)	2.15 (0.13)◦
Log-transformed tau/Aβ ratio	−0.28 (0.29)	−0.19 (0.31)◦	−0.31 (0.26)	−0.15 (0.31)1◦2
AD	n = 52	n =48	n =7	n = 34
Log-transformed total tau, pg/mL	2.03 (0.23)	2.0 (0.20)	2.02 (0.23)	2.03 (0.21)
Log-transformed Aβ, pg/mL	2.15 (0.12)	2.1 (0.11)	2.09 (0.13)	2.13 (0.11)
Log-transformed tau/Aβ ratio	−0.12 (0.28)	−0.09 (0.25)	−0.07 (0.17)	−0.09 (0.25)

Values are means (SD). ¹Significant while covarying for age, gender, and education, ^◦p < 0.05, *p < 0.01, p-values are for FH+, FHp, or FHm versus FH−, except for cells marked with a², where FHp <FHm. Aβ, amyloid-β; AD, Alzheimer's disease; FH−, negative family history of dementia; FH+, positive family history of dementia; FHp, paternal only family history of dementia; FHm, maternal only family history of dementia; MCI, mild cognitive impairment; ND, no dementia.