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. Author manuscript; available in PMC: 2013 Mar 26.
Published in final edited form as: Xenobiotica. 2011 Oct 4;42(2):139–156. doi: 10.3109/00498254.2011.609570

Table 3.

Affinity of trans-arachidins for mCB1 and hCB2 receptors.

Ki (µM)
Drug mCB1 hCB2 hCB2/mCB1 Selectivity
WIN-55,212-2 0.0034 ± 1.6 (5) 0.0058 ± 1.2 (4) 1.7 Non-selective
tA1 5.6 ± 0.4 (3) 12.6 ± 1.7 (3) 2.3 Non-selective
tA3 17.5 ± 3.4 (3) 11.3 ± 0.6 (3) 0.6 Non-selective
tRes 14.3 ± 1.6 (5) 65.5 ± 12.4 (3) 4.6 CB1
tPice 11.7 ± 1.0 (3) 114 ± 7.8 (3) 9.7 CB1
tRes-3-OD-Glu >100 (3) >100 (3) NA NA
tRes-4′-OD-Glu >100 (3) >100 (3) NA NA

mCB1, mouse brain CB1; hCB2, human CB2; tPice, trans-piceatannol; tA1, trans-arachidin-1; tA3, trans-arachidin-3.