Table 3.
Ki (µM) | ||||
---|---|---|---|---|
Drug | mCB1 | hCB2 | hCB2/mCB1 | Selectivity |
WIN-55,212-2 | 0.0034 ± 1.6 (5) | 0.0058 ± 1.2 (4) | 1.7 | Non-selective |
tA1 | 5.6 ± 0.4 (3) | 12.6 ± 1.7 (3) | 2.3 | Non-selective |
tA3 | 17.5 ± 3.4 (3) | 11.3 ± 0.6 (3) | 0.6 | Non-selective |
tRes | 14.3 ± 1.6 (5) | 65.5 ± 12.4 (3) | 4.6 | CB1 |
tPice | 11.7 ± 1.0 (3) | 114 ± 7.8 (3) | 9.7 | CB1 |
tRes-3-OD-Glu | >100 (3) | >100 (3) | NA | NA |
tRes-4′-OD-Glu | >100 (3) | >100 (3) | NA | NA |
mCB1, mouse brain CB1; hCB2, human CB2; tPice, trans-piceatannol; tA1, trans-arachidin-1; tA3, trans-arachidin-3.