Fig. 3.

Sex hormone levels in FA-exposed and ozone-exposed wild type and SP-A (−/−) male and female mice during K. pneumoniae infection. After FA or ozone exposure and subsequent infection with K. pneumoniae, as described in the legend for Fig. 1, plasma was collected and analyzed at 12 and 24 h post-infection for sex hormone concentrations in males and females, as described in Methods. Data from non-infected and infected mice are shown on the left and right, respectively. DHT and estradiol concentrations in plasma from intact (I), FA-exposed (FA), and ozone-exposed (O₃) animals are shown with solid grey, open, and solid black bars, respectively. Significant differences are shown with brackets. The notations “*”, “O₃“ and “WT-KO” under the brackets are the same as those indicated in Fig. 1, and the notation “FA” under the bracket show significant differences between FA-exposed and intact mice. The number of mice was 5 for each condition from three independent experiments.