Fig. 1.

NE, adenosine, and CPA induced constrictions of sham MAs and MVs. (A–D) Representative traces of NE and adenosine-induced contractions. NE contracted MA (A) and adenosine had no effect (B). Arterial constriction was sustained throughout the period of NE application (A) and venous constriction showed rapid desensitization to NE (C). (D) Adenosine produced a sustained constriction in MV. (E) Different contractile responses in MA and MV caused by NE (10 μM arteries, 1 μM veins), adenosine (10 μM), and CPA (1 μM). Data are mean ± S.E.M. Data were analyzed using one-way analysis of variance (ANOVA) and Dunnett’s post-hoc test. *Significantly different between groups (P < 0.05).