Fig. 7.
Role of endogenous adenosine by A1R antagonist (DPCPX) in adrenergic transmission of sham and DOCA-salt rats. Dose-response curves of DPCPX were performed under a 10 Hz stimulus train to evoke NE oxidation currents and neurogenic contraction. (A) DPCPX increased NE current and contraction (B) in concentration-dependent manner in sham MAs, but not in MVs. DPCPX did not alter the amplitude of NE oxidation currents (C) and neurogenic contraction (D) in DOCA-salt arteries. Data are mean ± S.E.M. #Significantly different from baseline values. Data were analyzed using one-way analysis of variance (ANOVA) and Dunnett’s post hoc test. N indicates the number of animals in the experiment.