TABLE 1.

Analysis of concentration-response curves for the effects of the A₁R agonist, CPA, on norepinephrine oxidation currents recorded from the surface of mesenteric arteries (MAs) and veins (MVs) from sham and DOCA-salt rats

pIC₅₀ values and maximum inhibition were determined from nonlinear curve fits of concentration-response curves from individual preparations. Mean values were then compared using Student’s t test.

Mesenteric arteries	N	pIC50	% Max Inhibition
Sham	9	7.6 ± 0.2	94 ± 2.0
DOCA-salt	9	6.4 ± 0.3*	64 ± 4.2*
Sham	5	8.5 ± 0.5	95 ± 3.6
DOCA-salt	6	8.6 ± 0.2	99 ± 1.4

A₁R, A₁ adenosine receptors; CPA, N⁶ cyclopentyl-adenosine; DOCA, deoxycorticosterone acetate; pIC₅₀, negative log of the half maximal inhibitory drug concentration.

^*Significantly different from sham values (P < 0.05).