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. 2013 Apr;345(1):139–150. doi: 10.1124/jpet.112.201566

Fig. 1.

Fig. 1.

DHPG increases conductance in STN neurons. (A) DHPG (20 μM) evokes inward currents in SNR (−70 mV) and SNC (−60 mV) neurons, but produces an outward current in an STN neuron (at −70 mV). Truncated deflections in these and subsequent current records are artifacts caused by voltage steps that were used to measure series resistance or membrane conductance. (B) Current traces recorded during a series of hyperpolarizing voltage steps (from −70 to −140 mV) show that DHPG (20 μM) increases membrane conductance in an STN neuron. Wash indicates recording after DHPG was washed from the slice. Dashed line indicates zero current. (C) Summarized I-V plots showing whole-cell conductance before (control) and during superfusion with 20 µM DHPG (n = 25). Significant differences: *P < 0.05; **P < 0.01; Holm-Sidak pairwise tests. (D) Summarized I-V plots showing net (subtracted) currents evoked by DHPG in STN (n = 26), SNR (n = 10), and SNC (n = 5) neurons. Note that DHPG increased conductance in STN neurons but not in SNR or SNC neurons.