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. 2013 Apr;345(1):139–150. doi: 10.1124/jpet.112.201566

Fig. 3.

Fig. 3.

Diazoxide (300 µM) occludes DHPG-induced outward current. (A) Continuous current trace (at −70 mV) shows that outward current evoked by DHPG (20 µM) is occluded by outward current evoked by the K-ATP channel opener diazoxide. (B) I-V plots for the action of 20 µM DHPG before (control) and in the presence of diazoxide. Diazoxide significantly altered the DHPG I-V plot (n = 6). (C) I-V plots for a control experiment showing lack of effect of apamin (1 µM) on tolbutamide-sensitive current evoked by DHPG. Tolbutamide antagonized DHPG-evoked currents in the continued presence of apamin. Significant differences at specific test potentials: *P < 0.05; **P < 0.01; Holm-Sidak tests.