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. 2013 Apr;345(1):139–150. doi: 10.1124/jpet.112.201566

Fig. 7.

Fig. 7.

DHPG-evoked K-ATP conductance increase requires NO. (A) Current traces show that DHPG-evoked outward current (at −70 mV) is blocked by the NOS inhibitor l-NAME (200 μM). Note that DHPG caused an inward current in the presence of tolbutamide. (B) I-V plots show that l-NAME (200 μM) significantly altered the voltage-dependence of currents evoked by DHPG (P < 0.05, two-way ANOVA with RM). Note that l-NAME changed the slope conductance of DHPG-evoked currents from positive to negative (n = 8). Significant differences at specific test potentials: *P < 0.05; **P < 0.01; Holm-Sidak tests.