Fig. 9.

Loose-patch recordings show that tolbutamide augments DHPG-dependent acceleration of firing rate. (A) Representative voltage traces showing firing rate before and after DHPG (20 μM) in the absence and presence of tolbutamide (100 µM). DHPG was superfused for 5 minutes, and tolbutamide was superfused 10 minutes prior to repeat application of DHPG. Note that the excitatory effect of DHPG is more pronounced in the presence of tolbutamide. (B) Averaged responses showing that tolbutamide significantly potentiated the DHPG-induced increase in firing rate (n = 7; P < 0.001).