TABLE 2.

Time course inhibition of COX-1 by m-ASA

Effect of m-ASA on COX-1 enzyme activity was determined as a function of time before and after dialysis as detailed in Materials and Methods. Results are mean ± S.E.M. for five different determinations with enzymes assays being done in triplicates.

Time, min	m-ASA, 1 mM
	COX-1 Inhibition (%)
	Before Dialysis	After Dialysis
2	5.0 ± 1	4.2 ± 1
5	18 ± 2	13 ± 1
15	46 ± 2	20 ± 2*
30	54 ± 3	34 ± 1*
120	43 ± 2	27 ± 1*

ASA, acetyl salicylic acid (aspirin); COX, cyclooxygenase.

^*P < 0.05 compared with before dialysis.