. 2013 Apr;41(4):744–753. doi: 10.1124/dmd.112.050294

TABLE 3.

Accuracy of propofol in vivo clearance predicted using CL_int,P450 and CL_int,UGT data derived from different in vitro systems

Data are shown as mean (± S.D.) predicted CL/observed CL (%). Data for individual dose groups are detailed in Supplemental Table 2.

In Vitro Method Used to Obtain Microsomal CL_int,UGT	In Vitro Systems Used
In Vitro Method Used to Obtain Microsomal CL_int,UGT	Microsomes without BSA	Microsomes with BSA	Hepatocytes and HKMs and HIMs with BSA
Substrate depletion	16.8 (2.19)	33.1 (4.78)	28.3 (3.54)
Metabolite formation	13.7 (1.75)	34.7 (5.15)	26.4 (3.59)^a

^{^a}

Substrate depletion approach used to determine hepatocyte CL_int data.