TABLE 7.
Regiochemical distribution of hydroxyeicosatetraenoic acid (HETE) products formed during incubation of recombinant CYP2Js with arachidonic acid
Data for human CYP2J2 are shown for comparison.
| Protein | Regiochemical Distribution (% Total HETEs) |
||||||
|---|---|---|---|---|---|---|---|
| 20-HETE | 19-HETE | 15-HETE | 12-HETE | 11-HETE | 8-HETE | 5-HETE | |
| CYP2J2 | 17 | 19 | 14 | 7 | 10 | 20 | 13 |
| CYP2J5 | 1 | 1 | 18 | 0 | 10 | 23 | 47 |
| CYP2J6 | 2 | 1 | 34 | 8 | 11 | 25 | 20 |
| CYP2J8 | 7 | 28 | 9 | 18 | 8 | 21 | 9 |
| CYP2J9 | 3 | 1 | 33 | 11 | 12 | 25 | 14 |
| CYP2J11 | 11 | 1 | 28 | 2 | 11 | 24 | 23 |
| CYP2J12 | 2 | 1 | 35 | 4 | 13 | 21 | 26 |
| CYP2J13 | 22 | 28 | 13 | 3 | 7 | 13 | 14 |