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Schematic of deadenylation-dependent, AU-rich element (ARE)-mediated messenger ribonucleic acid (mRNA) degradation. The mRNA is depicted with a 5′-cap structure and 3′-poly(A) tail. The ARE is shown as the boxed AUUUA. The start and stop codons are highlighted. The sequential pathway involves exoribonucleolytic removal of the poly(A) tail, followed by decapping and subsequent 5′ → 3′ and/or 3′ → 5′ degradation.
