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. Author manuscript; available in PMC: 2013 Mar 26.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2010 Nov-Dec;1(3):457–473. doi: 10.1002/wrna.26

FIGURE 5.

FIGURE 5

Dynamics of the ARE/poly(U)-binding/degradation factor 1 (AUF1) complex of proteins and AU-rich element (ARE)-mediated mRNA decay. AUF1 interacts with eIF4G and the ARE. During ongoing translation, AUF1 is displaced from the ARE in a complex with poly(A)-binding protein (PABP), perhaps exposing the poly(A) tail to ribonucleases. This may require destruction of AUF1 by proteasomes. During heat shock, association of hsp70 with AUF1 may disrupt or block the AUF1-PABP interaction, leaving PABP free to remain bound to the poly(A) tail, thus masking it from ribonucleases.