Table 4.

Pro-oxidant effects of ascorbate in animal models.

Species	Cell type	Treatment	Effects	Ref
Balb/c nude mice	HT29 colon cancer	Asc 15 mg, 100, 1000 mg/kg, i.p., daily. 4 weeks.	7/7 mice survived at 1000 mg/kg. No carcinogenic invasion. Tumor volumes decrease. ARSs and EiFs genes down regulated.	[262]
Balb/c nude mice	K562 leukemia	Vit K3 10 mg/kg, i.p.; Asc 1 g/kg, i.p.	Asc+vit K3 decrease tumor growth.	[263]
Ncr nude mice	Ovcar5 ovarian cancer	Asc 4 g/kg, i.p., twice daily. 30 days.	No adverse effects. Decrease tumor growth.	[11]
Ncr nude mice	Pan02 pancreatic cancer	Asc 4 g/kg, i.p., daily. 14 days.	No adverse effects. Decrease tumor growth.	[11]
Ncr nude mice	9 L rat glioblastoma	Asc 4 g/kg, i.p., twice daily. 12 days.	No adverse effects. Decrease tumor growth. Prevent metastases.	[11]
Ncr nude mice	Pan02 pancreatic cancer	Asc 4 g/kg, i.p., daily; Gemcitabine 30, 60 mg/kg, i.p., every 4 days. 21 days.	No side effects except osmotic stress. Asc+Gem significantly decrease tumor growth.	[209]
Ncr nude mice	PANC-1 pancreatic cancer	Asc 4 g/kg, i.p., daily; Gemcitabine 30, 60 mg/kg, every 4 days. 33 days.	No side effects except osmotic stress. Asc+Gem significantly decrease tumor growth.	[209]
Nude mice	MIA PaCa-2 pancreatic cancer	Asc 4 g/kg, i.p., twice daily. 14 days.	No adverse effects. Decrease tumor growth.	[12]
NMRI mice	TLT Murine hepatoma	Asc 1 g/kg, i.p., daily. 30 days.	Decrease tumor growth.	[164]
Nude mice	H322 non-small cell lung cancer	Asc 250 mg/kg, i.p.; 101 F6 nanoparticle i.v.	Asc synergistic with 101 F6 decrease tumor growth.	[264]
SCID mice	EHMS-10 mesothelioma cells	Asc 0.88, 8.8 g/mouse, i.v. single dose.	Decrease tumor growth.	[265]
Balb/c mice	Murine sarcoma S180 cells	Asc 5.5, 30 mg/mouse, i.p., every two days.	Decrease tumor growth; inhibit bFGF, VEGF and MMP2 genes.	[266]
Balb/c mice	Murine sarcoma S180 cells	Asc 1.5 mg/g, i.p., every three days.	Inhibit tumor establishment; RKIP and annexin A5 levels increase.	[267]