Fig 3.

Tangle-predominant dementia (TPD) is associated with low levels of Aβ. a–c Immunohistochemistry with antisera targeting Aβ in the frontal cortex (BA9) reveals Aβ deposition in control and Alzheimer disease (AD), but not TPD. Scale bar 1 mm. d ELISA performed in BA9 and the hippocampus (CA1) shows that AD patients have significantly higher Aβ42 levels than TPD and controls. (e) In BA9, AD patients have significantly higher Aβ40 than TPD patients and control, but there is no difference in CA1. f The ratio of Aβ42/Aβ40 is not different in BA9 among TPD, AD and control, but is significantly increased in AD compared to TPD and controls in CA1. Comparisons are by one-way ANOVA and Tukey’s test, *p < 0.05, **p < 0.01, ***p < 0.001