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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Acta Neuropathol. 2012 Jul 17;124(5):693–704. doi: 10.1007/s00401-012-1017-1

Fig 4.

Fig 4

Tangle-predominant dementia (TPD) is associated with alterations in APP metabolism. a, b Representative quantitative immunoblot on extracts from BA9 normalized to GAPDH shows significantly lower levels of APP in TPD than controls. TPD patients have significantly higher levels of sAPPα and significantly lower levels of sAPPβ than controls in the frontal cortex. c There is no difference in the levels of the APP mRNA among TPD, AD and control. Comparisons are by Student’s t test (b) or one-way ANOVA/ Tukey’s test (c) or *p < 0.05, **p < 0.01, ***p < 0.001