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. Author manuscript; available in PMC: 2014 Apr 25.
Published in final edited form as: Virology. 2013 Feb 28;439(1):57–64. doi: 10.1016/j.virol.2013.01.022

Table 1.

Kinetics of DENV-3 DIII-MPB variants with 8A1.

DIII Variant 301 383 ka (105M−1s−1) kd (10−3s−1) KD (nM) t ½ (sec) FRNT50 (ug/ml)
III T N 2.176 43.51 200.9 16.6 13.5*
I L K 1.124 11.51 103.2 60.5 0.20
II L K 0.268 12.62 470.9 59.0 0.37
T301L L N 0.6892 10.15 155.3 68.2 1.08
N383K T K 0.823 59.8 718.2 11.9 3.50
IV S K NA NA NA NA 413.1
*

There are two genotype III virus clones: SL ’89 and Cuba ’02. FRNT50 of SL ’89 (III) was indicated in this table and FRNT50 of Cuba ’02 (III) is 9.9 ug/ml. 8A1 binding was not detected for genotype IV DIII-MBP at concentrations of 5000 nM.