. Author manuscript; available in PMC: 2013 Nov 1.

Published in final edited form as: Mol Genet Metab. 2012 Aug 18;107(3):308–314. doi: 10.1016/j.ymgme.2012.08.006

Table 4.

Correlation of Blood Ammonia with Glycerol Phenylbutyrate (GPB) or Sodium Phenylbutyrate (NaPBA) Metabolites

Metabolite	Variable	GPB (N=65)		NaPBA (N=65)		Overall (N=130)
Metabolite	Variable	Coefficient (r)^a	p-value^a	Coefficient (r)^a	p-value^a	Coefficient (r)^a	p-value^a
U-PAGN Excretion	0–24–h	0.088	0.485	0.183	0.144	0.141	0.109
	0–12 h	0.278	0.025	0.122	0.333	0.204	0.020
	12–24 h	−0.045	0.719	0.197	0.115	0.068	0.445
Plasma PAGN	AUC_0–24	−0.087	0.497	0.138	0.277	0.028	0.759
	24 h (trough)	−0.097	0.444	0.037	0.774	−0.042	0.634
	12 h (peak)	−0.036	0.783	0.127	0.315	0.050	0.580
Plasma PAA	AUC_0–24	0.129	0.317	0.340	0.007	0.236	0.008
	24 h (trough)	−0.078	0.553	0.154	0.244	0.011	0.904
	12 h (peak)	0.172	0.182	0.251	0.044	0.228	0.010
Plasma PBA	AUC_0–24	0.040	0.756	0.227	0.074	0.131	0.142
	24 h (trough)	−0.082	0.535	0.173	0.195	0.011	0.903
	12 h (peak)	−0.037	0.775	0.005	0.970	−0.004	0.962

PAA = phenylacetic acid, PAGN = phenylacetylglutamine, PBA = phenylbutyric acid, U-PAGN = urinary phenylacetylglutamine, GPB = glycerol phenylbutyrate. NaPBA = sodium phenylbutyrate.

Correlation obtained using the Spearman rank-order correlation.