Table 3.

Adjusted odds ratios with 95% confidence intervals, p-values and sample sizes for each biomarker by lumbar disc space narrowing and anterior vertebral osteophytes.

	Disc Space Narrowing		Osteophytes
Biomarker (unit of measure)	Adjusted OR (95%CI)	p-value	Adjusted OR (95% CI)	p-value
lnCTX-II* (ng/mM Cr)	1.49 (1.15, 1.92)	<0.01	1.33 (1.02, 1.72)	0.03
lnNTX-I (nMBCE/mMCr)	1.27 (1.01, 1.60)	0.04	0.82 (0.65, 1.05)	0.11
lnCP-II* (ng/ml)	1.68 (1.09, 2.61)	0.02	0.88 (0.56, 1.38)	0.58
lnC2C* (ng/ml)	1.77 (0.96, 3.24)	0.07	1.10 (0.60, 2.00)	0.76
lnCOMP* (ng/ml)	1.18 (0.76, 1.81)	0.46	1.08 (0.70, 1.67)	0.73
lnHA* (ng/ml)	1.21 (1.01, 1.45)	0.04	1.09 (0.91, 1.31)	0.34

C-terminal crosslinked telopeptide (CTX-II) measured in nanogram per millimole, accounting for creatinine clearance. Cross-linked N-telopeptides (NTX-I) measured in nanomole of bone equivalents accounting for creatinine clearance. C-Propeptide (CP-II), Cleavage of type II collagen (C2C), Cartilage oligomeric matrix protein (COMP) and Hyaluronic Acid (HA) all measured in nanograms per milliliter. OR=odds ratio. CI=confidence interval. All models adjusted for age, race, gender, BMI and the other outcome.

^*adjusted for knee OA.