Figure 7. Activation of Gβγ subunits reduces DAT activity in vivo.

(A) Clearance of exogenously applied DA from the striatum of anesthetized mice. Once a baseline for DA clearance was established, mSIRK or scr-mSIRK was applied, and then 5 min later, DA was applied and again, 10, 20, 30 and 40 min after the peptides were introduced (arrows). The amplitude of the DA signal augment as observed in a representative traces of DA signal after intrastriatal injection of mSIRK (upper panel) or scb-mSIRK (bottom panel). (B) Clearance time (T₈₀) of exogenous DA was increased in the presence of mSIRK treatment. **p<0.01, *p<0.05.