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. 2013 Mar 26;8(3):e59782. doi: 10.1371/journal.pone.0059782

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© 2013 Bellei et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Quantitative RT-PCR analysis was performed for each sample in triplicate. The median ΔΔC_t value, calculated as reported in Fig.1. Each patient sample (n = 11) was directly compared with all control samples (n = 15) and values represent the means ± SD of fold increase of p53 target genes. (B) The increased expression of GADD45a and PML were also confirmed at protein level by western blot and densitometric analysis (VHM = 9; NHM = 9). For PML two different isoforms were detected and quantified separately. (C) Representative analysis of intracellular distribution of PML by immunofluorescence analysis (VHM = 6; NHM = 6). Nuclei were labelled with bisbenzidine (DAPI). Original magnification 63x. *p≤0.05.