Table 2. Clinicopathological features by protein expression status.
| Factor (N) | HR expression [N(%)] | OR (95% CI) | HER2 expression [N(%)] | OR (95% CI) | MYC expression [N(%)] | OR (95% CI) | |||
| Negative | Positive* | Negative | Positive* | Negative | Positive* | ||||
| Age | |||||||||
| ≤40 (27) | 15 (12.93) | 12 (10.34) | 1.117 (0.470–2.655) | 12 (10.34) | 15 (12.93) | 0.495 (0.207–1.182) | 12 (10.34) | 15 (12.93) | 0.247 (0.100–0.610)** |
| >40 (89)* | 47 (40.52) | 42 (36.21) | 55 (47.41) | 34 (29.31) | 68 (58.62) | 21 (18.10) | |||
| Grade | |||||||||
| 1/2 (96) | 46 (39.66) | 50 (43.10) | 0.230 (0.072–0.738)** | 61 (52.59) | 35 (30.17) | 4.067 (1.433–11.537)** | 67 (57.76) | 29 (25.00) | 1.244 (0.450–3.439) |
| 3 (20)* | 16 (13.79) | 4 (3.45) | 6 (5.17) | 14 (12.07) | 13 (11.21) | 7 (6.03) | |||
| Tumor invasion | |||||||||
| T1/T2 (9) | 4 (3.45) | 5 (4.31) | 0.676 (0.172–2.656) | 6 (5.17) | 3 (2.59) | 1.508 (0.358–6.352) | 7 (6.03) | 2 (1.72) | 1.630 (0.322–8.264) |
| T3/T4 (107)* | 58 (50) | 49 (42.24) | 61 (52.59) | 46 (39.66) | 73 (62.93) | 34 (29.31) | |||
| Lymph node metastasis | |||||||||
| Absent (6) | 6 (5.17) | 0 (0) | <0.001 (0) | 2 (1.72) | 4 (3.45) | 0.346 (0.061–1.971) | 3 (2.59) | 3 (2.59) | 0.429 (0.082–2.235) |
| Present (110)* | 56 (48.28) | 54 (46.55) | 65 (56.03) | 45 (38.79) | 77 (66.38) | 33 (28.45) | |||
| Response to therapy | |||||||||
| Sensitive (50) | 8 (6.90) | 42 (36.21) | 0.042 (0.016–0.113)** | 42 (36.21) | 8 (6.9) | 8.610 (3.483–21.283)** | 41 (35.34) | 9 (7.76) | 3.154 (1.318–7.547)** |
| Resistant (66)* | 54 (46.55) | 12 (10.34) | 25 (21.55) | 41 (35.34) | 39 (33.62) | 27 (23.28) | |||
| HR expression | |||||||||
| Negative (62) | – | – | – | 24 (20.69) | 38 (32.76) | 0.162 (0.070–0.373)** | 37 (31.90) | 25 (21.55) | 0.379 (0.164–0.872)** |
| Positive (54)* | – | – | 43 (37.07) | 11 (9.48) | 43 (37.07) | 11 (9.48) | |||
| HER2 expression | |||||||||
| Negative (67) | – | – | – | – | – | – | 56 (48.28) | 11 (9.48) | 5.303 (2.255–12.473)** |
| Positive (49)* | – | – | – | – | 24 (20.69) | 25 (21.55) | |||
*
Reference group for logistic regression analysis; ** Differentially expressed between groups, p<0.05. N: number of samples; OR: odds ratio; CI: confidence interval. HR: hormone receptor.