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. 2013 Mar 26;8(3):e60448. doi: 10.1371/journal.pone.0060448

Figure 1. Bioinformatics prediction of c*1043A>C mutation position and effect on miRNA affinity.

Figure 1

A–B) schematic diagram of the two in silico predicted miRNAs aligned with either wild-type (in green) or c.*1043A>C (in red) mutation of CFTR 3′UTR. C–D) predicted wild-type or CFTR 3′UTR-c.*1043A>C mutation Hybrid structure with miR-433. E–F) predicted wild-type or CFTR 3′UTR-c.*1043A>C mutaion Hybrid structure with miR-509-3p, for each hybrid structure is shown the mean free energy (mfe) calculated using the RNAHybrid server.