Figure 4. The proposed CHAO substrate egress route.

Cartoon figure of CHAO (blue) showing the principal egress route for cyclohexanone identified by RAMD (yellow). The flexible loop covering the entrance cavity (residues 118–128) is colored red and two important residues along the egress path (F351 and Y118) are shown as magenta sticks. The FAD cofactor is shown as sticks.