Table 4. Association between genotypes and TNBC risk.
| SNP ID (miRNA name) | Genotypes | Distribution frequencies of genotypes | OR(95%CI)a | P value | |
| Case | Control | ||||
| rs12983273 (hsa-mir-373) | CC | 161(0.8610) | 160(0.8743) | 0.8901[0.4874,1.6255] | 0.7258 |
| TT | 1(0.0053) | 2(0.0109) | 0.4866[0.0437,5.4130] | ||
| CT | 25(0.1337) | 21(0.1148) | 1.1905[0.6406,2.2123] | ||
| rs10425222 (hsa-mir-373) | CC | 149(0.7968) | 154(0.8191) | 0.8657[0.5175,1.4483] | 0.8571 |
| AA | 1(0.0053) | 1(0.0053) | 1.0054[0.0624,16.1940] | ||
| AC | 37(0.1979) | 33(0.1755) | 1.1586 [0.6886,1.9492] | ||
| rs1834306 (hsa-mir-100) | CC | 60(0.3141) | 55(0.2895) | 1.1242[0.7256,1.7417] | 0.4544 |
| TT | 38(0.1990) | 48(0.2526) | 0.7347[0.4533,1.1910] | ||
| CT | 93(0.4869) | 87(0.4579) | 1.1235[0.7513,1.6802] | ||
| rs2043556 (hsa-mir-605) | AA | 42(0.4330) | 68(0.4387) | 0.9770[0.5856,1.6300] | 0.9924 |
| GG | 4(0.0412) | 6(0.0387) | 1.0681[0.2936,3.8857] | ||
| AG | 51(0.5258) | 81(0.5226) | 1.0129[0.6094,1.6836] | ||
| rs2081443 (hsa-mir-125b-1) | TT | 98(0.5185) | 81(0.4332) | 1.4093[0.9387,2.1157] | 0.2501 |
| GG | 18(0.0952) | 20(0.1070) | 0.8789[0.4491,1.7203] | ||
| GT | 73(0.3862) | 86(0.4599) | 0.7391[0.4903,1.1141] | ||
| rs2114358 (hsa-mir-1206) | TT | 110(0.5729) | 108(0.5654) | 1.0309[0.6880,1.5449] | 0.2333 |
| CC | 10(0.0521) | 4(0.0209) | 2.5687[0.7914,8.3375] | ||
| CT | 72(0.3750) | 79(0.4136) | 0.8506[0.5644,1.2821] | ||
| rs2289030 (hsa-mir-492) | CC | 127(0.6615) | 114(0.5969) | 1.3197[0.8707,2.0002] | 0.1986 |
| GG | 5(0.0260) | 11(0.0576) | 0.4375[0.1491,1.2842] | ||
| CG | 60(0.3125) | 66(0.3455) | 0.8609[0.5619,1.3190] | ||
| rs2368392 (hsa-mir-604) | CC | 99(0.5156) | 99(0.5211) | 0.9785[0.6550,1.4618] | 0.9923 |
| TT | 15(0.0781) | 15(0.0789) | 0.9887[0.4691,2.0838] | ||
| CT | 78(0.4063) | 76(0.4000) | 1.0263[0.6819,1.5448] | ||
| rs2910164 (hsa-mir-146a) | CC | 63(0.3281) | 64(0.3351) | 0.9691[0.6333,1.4831] | 0.9875 |
| GG | 35(0.1823) | 34(0.1780) | 1.0294[0.6113,1.7336] | ||
| CG | 94(0.4896) | 93(0.4869) | 1.0108[0.6770,1.5090] | ||
| rs318039 (hsa-mir-1274a) | CC | 146(0.7604) | 142(0.7513) | 1.0505[0.6582,1.6767] | 0.762 |
| TT | 3(0.0156) | 5(0.0265) | 0.5841[0.1376,2.4795] | ||
| CT | 43(0.2240) | 42(0.2222) | 1.0101[0.6235,1.6363] | ||
| rs4919510 (hsa-mir-608) | GG | 57(0.2969) | 61(0.3211) | 0.8929[0.5783,1.3785] | 0.2544 |
| CC | 37(0.1927) | 47(0.2474) | 0.7263[0.4463,1.1820] | ||
| CG | 98(0.5104) | 82(0.4316) | 1.3731[0.9176,2.0548] | ||
| rs531564 (hsa-mir-124-1) | CC | 126(0.6923) | 136(0.7196) | 0.8768[0.5608,1.3711] | 0.3519 |
| GG | 4(0.0220) | 8(0.0423) | 0.5084[0.1504,1.7186] | ||
| CG | 52(0.2857) | 45(0.2381) | 1.2800[0.8047,2.0361] | ||
| rs5970292 (hsa-mir-105-2) | GG | 93(0.5254) | 111(0.5842) | 0.7845[0.5217,1.1798] | 0.5057 |
| AA | 22(0.1243) | 11(0.0579) | 1.1287[0.4851,2.6262] | ||
| AG | 62(0.3503) | 68(0.3579) | 1.2509[0.8245,1.8979] | ||
| rs5970293 (hsa-mir-105-1) | GG | 119(0.6230) | 102(0.5397) | 1.1099[0.7406,1.6633] | 0.3608 |
| CC | 12(0.0628) | 17(0.0899) | 0.5590[0.2490,1.2547] | ||
| CG | 60(0.3141) | 70(0.3704) | 1.0517[0.6944,1.5929] | ||
| rs6505162 (hsa-mir-423) | CC | 127(0.6615) | 110(0.5820) | 1.4032[0.9258,2.1267] | 0.278 |
| AA | 8(0.0417) | 10(0.0529) | 0.7783[0.3003,2.0168] | ||
| AC | 57(0.2969) | 69(0.3651) | 0.7343[0.4784,1.1270] | ||
| rs7372209 (hsa-mir-26a-1) | CC | 109(0.5677) | 99(0.5183) | 1.2204[0.8159,1.8254] | 0.5407 |
| TT | 19(0.0990) | 18(0.0942) | 1.0556[0.5357,2.0799] | ||
| CT | 64(0.3333) | 74(0.3874) | 0.7905[0.5204,1.2009] | ||
| rs895819 (hsa-mir-27a) | TT | 97(0.5132) | 106(0.5579) | 0.8355[0.5577,1.2516] | 0.6783 |
| CC | 16(0.0847) | 14(0.0737) | 1.1627[0.5507,2.4549] | ||
| CT | 76(0.4021) | 70(0.3684) | 1.1530[0.7621,1.7444] | ||
| rs1867863 (hsa-mir-10b) | AA | 78(0.4105) | 74(0.3936) | 1.0729 [0.7111,1.6187] | 0.8465 |
| CC | 30(0.1579) | 21(0.1117) | 1.4911 [0.8197,2.7124] | ||
| AC | 82(0.4316) | 93(0.4947) | 0.7756 [0.5172,1.1630] | ||
| rs1077020 (hsa-mir-943) | CC | 105(0.5707) | 100(0.5348) | 1.1563 [0.7677,1.7417] | 0.696 |
| TT | 5(0.0272) | 4(0.0214) | 1.2779 [0.3377,4.8361] | ||
| CT | 74(0.4022) | 83(0.4439) | 0.8429 [0.5581,1.2732] | ||
| 11614913 (hsa-mir-196a2) | TT | 54(0.2842) | 59(0.3155) | 0.8614 [0.5542,1.3389] | 0.4833 |
| CC | 44(0.2316) | 49(0.2620) | 0.8488 [0.5311,1.3565] | ||
| CT | 92(0.4842) | 79(0.4225) | 1.2834 [0.8548,1.9269] | ||
| rs16827546 (hsa-mir-30c-1) | CC | 165(0.8730) | 172(0.9149) | 0.6395 [0.3280,1.2469] | 0.4066 |
| TT | 2(0.0106) | 1(0.0053) | 2.0000 [0.1798,22.2466] | ||
| CT | 22(0.1164) | 15(0.0798) | 1.5194 [0.7622,3.0288] | ||
| rs17276588 (hsa-let-7f-2) | GG | 92(0.4894) | 97(0.5160) | 0.8991 [0.6000,1.3472] | 0.8754 |
| AA | 18(0.0957) | 17(0.0904) | 1.0651 [0.5310,2.1363] | ||
| AG | 78(0.4149) | 74(0.3936) | 1.0924 [0.7235,1.6494] | ||
| rs2292832 (hsa-mir-149) | TT | 99(0.5351) | 100(0.5376) | 0.9900 [0.6583,1.4889] | 0.2846 |
| CC | 17(0.0919) | 26(0.1398) | 0.6227 [0.3256,1.1911] | ||
| CT | 69(0.3730) | 60(0.3226) | 1.2491 [0.8141,1.9167] | ||
a
Adjusted for age and smoking status.
P trend : calculated by Cochran–Armitage trend test.