Table 1. Examples of drug-target associations previously determined, that were correctly identified in the present study.

Drug(s)	P. falciparum target(s) ID	Identity to (E-value or score)	Pathway	Reference(s)
Several quinolones	DNA GyrAse a-subunit, putative PF3D7_1223300	DNA gyrase subunit A (P72524 - GYRA_STRPN) (1e−50)	Replication	[8]
Fusidic acid	elongation factor G, putativePF3D7_0602400	Elongation factor G (P13551 - EFG_THETH) (8.7e−75)	Translation	[17]
Tetracycline	apicoplast ribosomal protein S14p/S29eprecursor, putative PF3D7_1137500	30S ribosomal protein S14 (P0AG59 - RS14_ECOLI) (7.5e−15)	Translation	[32]
Fosmidomycin	1-deoxy-D-xylulose 5-phosphatereductoisomerase PF3D7_1467300	0.99	Isoprenoid biosynthesis	[16]
Triclosan	enoyl-acyl carrier reductase PF3D7_0615100	0.99	Fatty acid synthesis	[8]
Geldanamycin	heat shock protein 90, putative	0.80	Protein folding	[33]
Halofantrine	plasmepsin VIII PF3D7_1465700	Plasmepsin-2 (P46925 - PLM2_PLAFA) (9e−23)	Proteolysis	[31]

(codes in brackets represent the target Identity Code of DrugBank. In the cases of Fosmidomycin, Triclosan and Geldanamycin, there are no homologous targets represented because they were identified using STITCH3.1 which uses an algorithm where homologous targets are not displayed).