Table 4. The enriched pathways among top 100 genetic mediators identified by the MNI analysis at each time point in the epididymal fat tissue of HFD-induced obese mice.

		GO ontology	Ranked pathway genes (rank)
Epididymal fat tissue
2 week	Olfactory transduction		Adrbk2 (4), Olfr513 (6), Olfr433 (15), Camk2g (28), Olfr1245 (29), Olfr1143 (36), Olfr996 (55), Olfr960 (57), Arrb2 (79)
	Wnt signaling pathway		Camk2g (28), Rhoa (31), Wnt10a (95)
	Melanogenesis		Camk2g (28), Adcy5 (80), Wnt10a (95)
	Chemokine signaling pathway		Rhoa (31), Arrb2 (79), Adcy5 (80)
	Focal adhesion		Rhoa (31), Lamc3 (44), Bcl2 (77)
	Pathways in cancer		Rhoa (31), Bcl2 (77), Wnt10a (95)
4 week	Olfactory transduction		Camk2g (17), Olfr513 (27), Olfr960 (31), Olfr1245 (43), Arrb2 (55)
	Pathways in cancer		Gli2 (1), Lamc3 (9), Bcl2 (58), Fgf5 (65)
	MAPK signaling pathway		Arrb2 (55), Fgf5 (65), Mapkapk5 (75)
	Purine metabolism		Gucy2c (2), Nme7 (47), Cant1 (85)
8 week	Olfactory transduction		Olfr536 (11), Olfr513 (31), Olfr654 (37), Camk2g (74), Olfr652 (99)
	Focal adhesion		Flnc(16), Bcl2 (64), Col6a2 (83), Rhoa (86), Mylk (96),
	Regulation of actin cytoskeleton		Fgf5 (26), Rhoa (86), Mylk (96)
	Pathways in cancer		Fgf5 (26), Bcl2 (64), Rhoa (86)
12 week	Olfactory transduction		Olfr16 (6), Camk2g (10), Olfr715 (24), Olfr1245 (32), Olfr536 (36), Olfr1143 (52)
	Neuroactive ligand-receptor interaction		Pth2r (1), Agtrl1 (16), Vipr2 (27), P2rx6 (74)
	Focal adhesion		Lamc3 (4), Bcl2 (75), Col6a2 (76), Rhoa (88)
	ECM-receptor interaction		Lamc3 (4), Cd44 (59), Col6a2 (76)
	Pathways in cancer		Lamc3 (4), Bcl2 (75), Rhoa (88)