Table 5. The enriched pathways among top 100 genetic mediators identified by the MNI analysis at each time point in the subcutaneous fat tissue of HFD-induced obese mice.

	GO ontology	Ranked pathway genes (rank)
Subcutaneous fat tissue
2 week	Olfactory transduction	Camk2b (2), Olfr1173 (5), Olfr823 (9), Guca1a (41), Olfr411 (49), Olfr1408 (51), Olfr875 (64)
	Calcium signaling pathway	Camk2b (2), Cacna1d (15), Htr4 (45), Ryr1 (96)
	GnRH signaling pathway	Camk2b (2), Cacna1d (15), Cga (48)
4 week	Olfactory transduction	Olfr855 (2), Olfr888 (13), Olfr305 (36), Olfr1173 (49), Olfr395 (52), Olfr411 (55), Olfr823 (83), Olfr1409 (89)
	Axon guidance	Sema6a (3), Abl1 (23)
	Cell cycle	Ccnb3 (5), Abl1 (23)
	Regulation of actin cytoskeleton	Vav3 (9), Ssh2 (25)
	Tyrosine metabolism	Fah (26), Aoc3 (27)
	MAPK signaling pathway	Cacna1d (28), Hspa1a (44)
8 week	Olfactory transduction	Olfr1056 (3), Olfr960 (15), Olfr1408 (26), Olfr855 (35), Olfr609 (42), Olfr1173 (49), Olfr411 (71), Olfr205 (91), Olfr1121 (94)
	Focal adhesion	Shc4 (63), Diap1 (77), Lamb2 (82), Vav3 (83)
12 week	Olfactory transduction	Olfr716 (4), Olfr45 (16), Olfr960 (19), Olfr1173 (32), Olfr411 (34), Olfr1408 (43), Olfr855 (45), Olfr875 (96)
	GnRH signaling pathway	Cacna1d (29), Cga (58)
	Chemokine signaling pathway	Vav3 (33), Gng3 (79), Shc4 (84)