Table 6. The enriched pathways among top 100 genetic mediators identified by the MNI analysis at each time point in the gastrocnemius muscle of HFD-induced obese mice.

	GO ontology	Ranked pathway genes (rank)
Gastrocnemius muscle
2 week	Olfactory transduction	Clca3 (6), Olfr739 (14), Olfr488 (40), Olfr474 (55)
4 week	Olfactory transduction	Olfr800 (28), Olfr978 (33), Olfr474 (49), Olfr488 (73)
	Neuroactive ligand-receptor interaction	Oprl1 (30), Mc1r (78), Tbxa2r (89), Tspo (97)
	Cytokine-cytokine receptor interaction	Eda2r (2), Il13 (3), Cx3cl1 (91)
	Pathways in cancer	Dcc (10), Amn (71), Mlh1 (85)
8 week	Olfactory transduction	Clca3 (9), Olfr739 (48), Olfr1305 (64), Olfr1395 (80), Olfr140 (81), Olfr63 (85), Olfr689 (86)
	Pathways in cancer	Mapk9 (4), Dcc (15), Mapk10 (78), Grb2 (87), Mitf (89)
	Insulin signaling pathway	Mapk9 (4), Irs3 (40), Mapk10 (78), Grb2 (87)
	Colorectal cancer	Mapk9 (4), Dcc (15), Mapk10 (78), Grb2 (87)
	Adipocytokine signaling pathway Type II diabetes mellitus	Mapk9 (4), Irs3 (40), Mapk10 (78)
12 week	Olfactory transduction	Olfr689 (22), Olfr488 (24), Olfr347 (38), Olfr1204 (69)
	Cell adhesion molecules (CAMs)	Cd22 (23), Nlgn3 (44), Ptprm (62)
	Cytokine-cytokine receptor interaction	Eda2r (43), Ppbp (53), Cx3cl1 (57)