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. 2013 Mar 26;8(3):e59434. doi: 10.1371/journal.pone.0059434

Figure 4. TcVac3-immunized mice responded to challenge T. cruzi infection by a strong expansion of parasite- and antigen-specific antibody response.

Figure 4

Mice were immunized as in Fig. 1, and challenged with T. cruzi (10,000/mouse). The sera levels of antigen-specific (A&C) and TcTL-specific (B&D) IgG, IgG2b and IgG1 antibodies were measured at day 30 (A&B) and 120 (C&D) post-infection by an ELISA. (E–H). Shown are antigen-specific (E&G) and TcTL-specific (F&H) percent avidity of the antibodies induced in vaccinated/infected mice at day 30 (E&F) and 120 (G&H) pi. (I&J) Trypanolytic activity of sera antibodies induced in vaccinated/infected mice at day 30 (I) and 120 (J) pi.