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Salmeterol-induced neurotoxicity is through β2AR. ICI118,551was added to rat mesencephalic midbrain neuron-glia cultures for 30 min prior to the addition of salmeterol. DA neurotoxicity was quantified on day 7 using the [3H]-DA uptake assay. Data are percentage of control cultures, and are presented as the mean ± SE of 3 separate experiments. *P<0.05 compared with the salmeterol-alone treated cultures without ICI118,551, ##P<0.01 when compared with the vechicle-treated cultures.
