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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: J Immunol. 2013 Feb 18;190(7):3480–3492. doi: 10.4049/jimmunol.1202675

Figure 3. HDM-sensitized Pglyrp1−/− mice have reduced cell infiltration and reduced goblet cell hyperplasia and metaplasia compared with WT mice.

Figure 3

(A) PAS staining of longitudinal lung sections along bronchial tree (Br) of untreated (top) and HDM-sensitized (bottom) WT (left) and Pglyrp1−/− (right) mice with massive inflammatory cell infiltrates (Ci) around bronchi, bronchioles, and pulmonary arteries (Ar) and veins (V) along the bronchial tree, with numerous large PAS+ mucin-producing goblet cells (G) lining the bronchial air spaces in WT, but not in Pglyrp1−/− mice; bar = 200 μm. (B) H&E staining of cellular infiltrates showing higher numbers of eosinophils (E) in WT than in Pglyrp1−/− mice; bar = 50 μm. (C) Numbers of PAS+ mucin-producing goblet cells lining the bronchial air spaces in WT and Pglyrp1−/− mice; means ± SEM of 6 mice/group; *, p < 0.00001; Pglyrp1−/− versus WT mice.