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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: J Immunol. 2013 Feb 18;190(7):3480–3492. doi: 10.4049/jimmunol.1202675

Figure 9. Depletion of pDC in vivo reverses attenuated asthma phenotype in HDM sensitized Pglyrp1−/− mice.

Figure 9

Pglyrp1−/− mice were treated with anti-pDC (anti-CD317) mAb or isotype control IgG during sensitization with HDM for 5 weeks. Anti-pDC mAb reduced the numbers of pDC in vivo (A). Depletion of pDC increased the numbers of eosinophils, neutrophils, lymphocytes, and macrophages in BAL cells and lungs (B), increased lung airway resistance (C), and increased numbers of CD4+ cells in BAL cells and CD4+, Th1, Th2, and Th17 cells in the lungs, and decreased the percentage of Treg cells in BAL cells and the lungs (D), measured by flow cytometry, with gating as shown in Figs. 7 and 8A; means ± SEM of 6 mice/group; *, p < 0.05; **, p < 0.005; anti-pDC versus IgG.