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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: J Immunol. 2013 Mar 1;190(7):3639–3647. doi: 10.4049/jimmunol.1203488

Figure 1. Fetal resorption and amplification of uterine NK and T cells in WT and IL-10−/− mice in response to poly(I:C) treatment.

Figure 1

(A) poly(I:C) injected i.p. on gd6 was evaluated in a dose dependent manner to induce fetal resorption as assessed by inspection of uterine placental units on gd10. A dose of 100 μg/mouse induced 100% fetal resorption in both IL-10−/− and WT mice. A subset of these mice was allowed to deliver and no pups were born. Data are plotted as mean ± S.E.M (n=6/treatment). (B) Representative gd10 WT and IL-10−/− uterine horns from mice treated with saline or 100 μg/mouse poly(I:C) are depicted. (C) Assessment of splenic and uterine immune cells from WT or IL-10−/− mice treated on gd6 with saline or poly(I:C) (100 μg/mouse) and harvested on gd10. Cellular populations were first gated on CD45+ cells then analyzed for NK1.1 versus CD3. Data from spleen and uterus are representative of 8 mice per condition and numbers are averages of these data. (D) Graphs indicate statistical significance (*, p<0.05) of saline versus poly(I:C) treated cellular populations as indicated.