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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Antiviral Res. 2012 Dec 22;97(3):232–239. doi: 10.1016/j.antiviral.2012.12.012

FIG. 6. GRL-002 and sinefungin binding to the SAM site of the WNV MTase.

FIG. 6

(A) Predicted structure of GRL-002 (stick representation) in the surrounding solvent-accessible surface of the MTase. Atomic color coding is as follows (unless otherwise specified): carbon in yellow/green, oxygen in red, nitrogen in blue, hydrogen in white, and silicon in orange. (B) Overlay of docked GRL002 and sinefungin in crystal structure (Dong et al., 2010a). The MTase residues in polar contacts with GRL-002 are also shown in stick format. Color coding is the same as in (A), except sinefungin carbons are shown in cyan.