. Author manuscript; available in PMC: 2014 Jul 1.

Published in final edited form as: Biochim Biophys Acta. 2012 Nov 9;1832(7):972–978. doi: 10.1016/j.bbadis.2012.11.001

Table 2.

Inhibitors of autophagy and their current clinical applications.

MECHANISM	COMPOUNDS	CURRENT CLINICAL USE?
Inhibition of the class III PI3K (Vps34) pathway	• 3-methyladenine
	• Wortmannin
	• LY294002
Impairment of AV fusion/alteration of lysosomal pH	• Chloroquine	• Antimalarial
Impairment of AV fusion/alteration of lysosomal pH	• Bafilomycin A1	• Macrolide antibiotic
Increase of cytosolic Ca⁺⁺ levels	• Thapsigargin
Increase of cytosolic Ca⁺⁺ levels	• Bay K8644
Inhibition of histone deacetylase	• Trichostatin A
Interaction with AMPK	• Dorsomorphin
Interaction with AMPK	• AICAR (5-aminoimidazole-4-carboxyamide ribonucleoside)