Skip to main content
. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Ann Neurol. 2012 Dec 7;73(2):199–209. doi: 10.1002/ana.23764

Figure 2. Dose-effect of passive focal cooling on focal neocortical epilepsy.

Figure 2

A) Schematic of the experimental protocol. One week after rpFPI rats are implanted with headsets A, B, C and D, providing graded cooling up to 2°C. B–C) The log-transformed seizure frequencies (B) and times spent seizing (C) measured 4 weeks after injury both varied as linear functions of the steady state temperatures (or inversely with the magnitude of cooling) measured in the perilesional neocortices of different rats implanted with the indicated headsets. Statistical significance shown is for seizure frequency or time seizing vs headset A. Statistical significance is color coded: black filled symbols indicate a statistically significant difference from controls (gray symbols). D) Seizures do not rebound acutely after termination of cooling in epileptic rats focally cooled with headsets C and D. Seizure frequencies and times spent seizing were measured in 7h recordings obtained at the same time of day on consecutive days during cooling and active rewarming to 36.5°C.