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Upregulated expression of ABCB1 correlates with increased carfilzomib resistance in KMS-34/Cfz cells. CD243(ABCB1) cell surface expression (top panels) and CDy1 efflux (bottom panels) are shown for KMS-34/Cfz and parental KMS-34 cells in comparison to RPMI-8226/Dox40 and parental RPMI-8226 cells. Percentages of CD243(ABCB1)-positive and CDy1-lo cells are indicated. For the CDy1 efflux assays, the positions of the far left gates were determined by autofluorescence of unstained cells.
