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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Hepatology. 2013 Feb 15;57(4):1530–1541. doi: 10.1002/hep.26187

Fig. 3. Isoform-dependent transactivation of human BSEP by FXR in vivo in mice.

Fig. 3

(A) Three groups of CD-1 female mice received human promoter reporter phBSEP(−2.6kb) and either pcDNA5 vector, FXRα1 or FXRα2 expression plasmid DNA through hydrodynamic tail vein injection. The transactivation levels were detected with IVIS Living Imaging system. Two representative mice from each group were presented. (B) Quantification of total signals (photons) in a fixed area covering the entire liver surface was carried out with Living Imaging Software and presented as mean± SD. The asterisk (*) indicates p<0.05 by the Student’s t-test. (C) FXR protein levels in the liver of FXRα1 or FXRα2-injected mice were detected with Western blot.