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Effects of rivaroxaban on the left atrial (LA) action potential (AP) and contractility. An example and average data (n = 7) show that rivaroxaban (10, 30, 100, and 300 nM) concentration-dependently shortened AP durations (APD20, APD50, and APD90) of LA. The resting membrane potential (RMP), AP amplitude (APA), and contractile forces of LA did not significantly change with rivaroxaban treatment. * P < 0.05, ** P < 0.01, *** P < 0.005 vs. control.
