Table 1.
Risk factors and demographics in patients diagnosed with hepatocellular carcinoma (HCC) in Scotland during 1985–2008 (n = 2802)
| 1985–1989 | 1990–1994 | 1995–1999 | 2000–2004 | 2005–2008 | |
|---|---|---|---|---|---|
| HCC diagnoses, n | 355 | 395 | 562 | 669 | 821 |
| Age, years, mean ± SD | 68.59 ± 11.27 | 67.63 ± 11.80 | 67.75 ± 10.92 | 68.49 ± 10.62 | 68.37 ± 10.74 |
| Male, n (%) | 265 (74.6%) | 297 (75.2%) | 421 (74.9%) | 511 (76.6%) | 644 (78.4%) |
| Deprivation quintile 1a, n (%) | 130 (36.6%) | 113 (28.6%) | 164 (29.2%) | 166 (24.9%) | 238 (29.0%) |
| Deprivation quintile 2, n (%) | 79 (22.3%) | 91 (23.0%) | 130 (23.1%) | 171 (25.6%) | 194 (23.6%) |
| Deprivation quintile 3, n (%) | 57 (16.1%) | 76 (19.2%) | 104 (18.5%) | 132 (19.8%) | 151 (18.4%) |
| Deprivation quintile 4, n (%) | 42 (11.8%) | 62 (15.7%) | 76 (13.5%) | 90 (13.5%) | 145 (17.7%) |
| Deprivation quintile 5, n (%) | 47 (13.2%) | 53 (13.4%) | 88 (15.7%) | 109 (16.3%) | 93 (11.3%) |
| Metastasesb, n (%) | 28 (8.0%) | 36 (9.3%) | 60 (10.7%) | 71 (10.6%) | 90 (11.1%) |
| Viral hepatitis, n (%) | 5 (1.4%) | 14 (3.6%) | 45 (8.0%) | 48 (7.2%) | 67 (8.2%) |
| Liver cirrhosis, n (%) | 95 (27.1%) | 112 (28.9%) | 161 (28.8%) | 130 (19.4%) | 202 (24.8%) |
| Alcoholic liver cirrhosisc, n (%) | 37 (10.5%) | 49 (12.6%) | 81 (14.5%) | 67 (10.0%) | 115 (14.1%) |
| Non-alcoholic liver cirrhosisd, n (%) | 58 (16.3% | 63 (15.9%) | 80 (14.2%) | 63 (9.4%) | 87 (10.6%) |
| Biliary cirrhosis, n (%) | 8 (2.3%) | 14 (3.6%) | 18 (3.2%) | 22 (3.3%) | 27 (3.3%) |
| Haemochromatosis, n (%) | 18 (5.1%) | 15 (3.9%) | 23 (4.1%) | 31 (4.6%) | 43 (5.3%) |
| Alcohol-related admission, n (%) | 56 (16.0%) | 73 (18.8%) | 131 (23.4%) | 158 (23.7%) | 220 (27.1%) |
| Diabetes, n (%) | 37 (10.5%) | 57 (14.7%) | 83 (14.8%) | 132 (19.7%) | 214 (26.3%) |
| Hypertension, n (%) | 12 (3.4%) | 21 (5.4%) | 49 (8.8%) | 92 (13.8%) | 189 (23.2%) |
| Ischaemic heart disease, n (%) | 28 (8.0%) | 43 (11.1%) | 78 (13.9%) | 89 (13.3%) | 125 (15.4%) |
| Transplant, n (%) | 0 | 4 (1.0%) | 14 (2.5%) | 32 (4.8%) | 34 (4.1%) |
| Histological verification, n (%) | 286 (80.6%) | 304 (77.0%) | 378 (67.3%) | 376 (56.2%) | 349 (42.5%) |
a
Deprivation quintile 1 represents the most deprived.
b
Admitted with metastases within 4 weeks of diagnosis.
c
Individuals with a diagnosis of liver cirrhosis and an alcohol-related admission.
d
Individuals with a diagnosis of liver cirrhosis and no alcohol-related admission.
SD, standard deviation.