Table 2.
Some studies that evaluate LIG4 polymorphisms role in cancer
| Authors | LIG4 SNP identification | Tumor model | Ethinicity | Result |
| Jakubowska et al[84] | rs1805386 | Ovarian and Breast Cancer | Caucasian | The polymorphism was not associated with BRCA1-associated ovarian and breast cancer risk (P = 0.16 and P = 0.97, respectively) |
| Schildkraut et al[82] | rs10131 | Ovarian Cancer | Caucasian | The polymorphism was significantly associated with invasive serous ovarian cancer risk (P < 0.05) |
| Pearce et al[83] | rs1805386 | Ovarian Cancer | Mixed | The polymorphism was initially associated with ovarian cancer risk (P = 0.007) but replication results do not confirm this association |
| Yin et al[93] | rs1805388 | Non-small cell Lung Cancer | Mixed | The polymorphism was significantly associated with the risk of severe radiation pneumonitis in non-small cell lung cancer patients who received radio(chemo)therapy (P < 0.05) |
| Tseng et al[94] | rs1805388 | Non-small cell Lung Cancer | Asian | The polymorphism was significantly associated with lung cancer risk (P = 0.038) especially in smoking patients (P = 0.015), and with high fractional allelic loss (P = 0.016) |
| de las Peñas et al[89] | rs1805386 | Non-small cell Lung Cancer | Caucasian | The polymorphism was not associated with survival in cisplatin/gemcitabine-treated non-small cell lung cancer patients (P = 0.31) |
| Sakiyama et al[95] | rs2232641 | Lung Cancer | Japanese | The polymorphism was significantly associated with a diminish risk to develop lung cancer (P = 0.03) |
| Sobczuk et al[96] | rs2232641 | Breast Cancer | Caucasian | The polymorphism was not associated with breast cancer risk (P > 0.05) |
| Han et al[97] | rs1805386 | Breast Cancer | Mostly Caucasian | No statistically differences in breast cancer risk according LIG4 C299T or T1977C. The polymorphism T1977C was significantly associated with breast cancer risk if the patients had a first degree family history of breast cancer (P = 0.01) |
| rs4987182 | ||||
| Goode et al[98] | rs1805386 | Breast Cancer | Caucasian | The polymorphism was significantly associated with the breast cancer survival (P = 0.002) |
| Kuschel et al[99] | rs1805386 | Breast Cancer | Caucasian | The polymorphism was significantly associated with a decrease in breast cancer risk (P = 0.04) |
| Liu et al[100] | rs3093739 | Glioma | Asian | The polymorphism was significantly associated with glioma risk (P = 0.009) |
| Liu et al[101] | rs7325927 | Glioblastoma | Caucasian | The polymorphism was significantly associated with glioblastoma survival (P = 0.008) |
SNP: Single nucleotide polymorphism.