Table 2. Genotypic frequencies and odds ratios for the association of CALHM1 and CALHM3 SNPs with sCJD (minor allele carriers vs. non-carriers).
| Gene |
SNP |
Genotypes |
Genotypic frequency, n(%) |
OR [95%CI] |
p-value* | |
|---|---|---|---|---|---|---|
| CONTROL | sCJD | |||||
|
CALHM1 |
rs2986016 |
CC |
172 (58.5) |
95 (56.5) |
1.08 [0.72–1.62] |
0.72 |
| |
|
TC |
113 (38.4) |
66 (39.3) |
||
| |
|
TT |
9 (3.1) |
7 (4.2) |
||
| |
|
Total |
294 (100) |
168 (100) |
||
| |
rs41287502 |
GG |
297(94.6) |
208(89.7) |
2.21 [1.12–4.34] |
0.02 |
| |
|
TG |
16(5.1) |
21(9.0) |
||
| |
|
TT |
1(0.3) |
3(1.3) |
||
| |
|
Total |
314(100) |
232(100) |
||
| |
rs2986017 |
CC |
181(55.0) |
115(49.6) |
1.26 [0.88–1.79] |
0.21 |
| |
|
TC |
128(38.9) |
94(40.5) |
||
| |
|
TT |
20(6.1) |
23(9.9) |
||
| |
|
Total |
329(100) |
232(100) |
||
| |
rs4918016 |
GG |
158(48.0) |
132(56.9) |
0.71 [0.50–1.00] |
0.05 |
| |
|
AG |
152(46.2) |
81(34.9) |
||
| |
|
AA |
19(5.8) |
19(8.2) |
||
| |
|
Total |
329(100) |
232(100) |
||
|
CALHM3 |
rs2986035 |
AA |
183 (59.6) |
133 (56.6) |
1.07 [0.74–1.53] |
0.72 |
| |
|
AG |
109 (35.5) |
97 (41.3) |
||
| |
|
GG |
15 (4.9) |
5 (2.1) |
||
| |
|
Total |
307 (100) |
235 (100) |
||
| |
rs3014199 |
AA |
294 (91.3) |
202 (86.3) |
1.72 [0.98–3.01] |
0.06 |
| |
|
AG |
28 (8.7) |
32 (13.7) |
||
| |
|
GG |
0 (0.0) |
0 (0.0) |
||
| Total | 322 (100) | 234 (100) | ||||
*
Adjusted significance level for six multiple comparisons p = 0.008