Table 1. Genotype and allele frequencies of the 1368 and 129 PRNP polymorphisms among sCJD patients and controls.
| |
sCJD n (%) |
Controls n (%) |
OR |
95% CI |
p value* |
|---|---|---|---|---|---|
| 1368 genotype | |||||
| TT |
21(45.6) |
35 (25.4) |
reference |
|
|
| TC |
16 (34.8) |
70 (50.7) |
0.381 |
0.177–0.820 |
0.018 |
| CC | 9 (19.6) | 33 (23.9) | 0.455 | 0.182–1.134 | 0.121 |
| 1368 allele | |||||
|---|---|---|---|---|---|
| T |
58 (63.0) |
140 (50.7) |
reference |
|
|
| C | 34 (37.0) | 136 (49.3) | 0.603 | 0.372–0.980 | 0.041 |
| 129 genotype | |||||
|---|---|---|---|---|---|
| AA |
24 (52.2) |
38 (27.5) |
3.411 |
1.512–7.758 |
0.0013 |
| AG |
15 (32.6) |
81 (58.7) |
reference |
|
|
| GG | 7 (15.2) | 19 (13.8) | 1.989 | 0.630–6.177 | 0.248 |
| 129 allele | |||||
|---|---|---|---|---|---|
| A |
63 (68.5) |
157 (56.9) |
reference |
|
|
| G | 29 (31.5) | 119 (43.1) | 1.647 | 0.971–2.802 | 0.051 |
| Genotype 1368–129 |
|||||
|---|---|---|---|---|---|
| TT-AA |
3 (6.5) |
8 (5.8) |
0.580 |
0.126–2.672 |
0.713 |
| TC-AA |
13 (28.2) |
11 (8) |
1.826 |
0.605–5.512 |
0.403 |
| CC-AA |
8 (17.4) |
19 (13.8) |
0.651 |
0.212–1.997 |
0.573 |
| TT-AG |
11 (24.0) |
17 (12.3) |
reference |
|
|
| TC-AG |
3 (6.5) |
50 (36.2) |
0.093 |
0.023–0.372 |
0.0003 |
| CC-AG |
1 (2.2) |
14 (10.1) |
0.110 |
0.013–0.963 |
0.033 |
| TT-GG |
7 (15.2) |
10(7.2) |
1.082 |
0.317–3.694 |
1.000 |
| TC-GG | 0 | 9 (6.5) | 0.036 |
*
Two-tailed Fisher’s exact test; OR, odds ratio; CI, confidence interval.