Table 3.
Multivariate mixed logistic regression analysis of factors predicting subtarget Hb levels.
| Variable | Model 1 (Excluding Serum Ferritin; n=3073) | Model 2 (Including Serum Ferritin; n=1781) | ||
|---|---|---|---|---|
| Odds Ratio (95% CI) | P Value | Odds Ratio (95% CI) | P Value | |
| Age at study entry (yr) | 1.03 (1.01–1.05) | 0.01 | 1.02 (0.996–1.05) | 0.10 |
| Time on PD before study entry (yr) | 1.04 (0.98–1.11) | 0.21 | 1.05 (0.96–1.14) | 0.27 |
| Study time (yr) | 0.96 (0.86–1.08) | 0.54 | 0.93 (0.81–1.07) | 0.33 |
| Pubertal male | 0.51 (0.38–0.70) | <0.001 | 0.50 (0.32–0.74) | <0.001 |
| Residual urine output (L/m2 per day) | 0.73 (0.62–0.85) | <0.001 | 0.81 (0.66–0.99) | 0.04 |
| PD fluid turnover (L/m2 per day) | 0.96 (0.93–0.99) | 0.01 | 0.94 (0.90–0.98) | 0.01 |
| Use of biocompatible PD fluids | 0.73 (0.59–0.91) | 0.005 | 0.70 (0.52–0.93) | 0.01 |
| Use of long-acting ESA | 0.995 (0.78–1.28) | 0.97 | 0.97 (0.71–1.32) | 0.84 |
| Use of intravenous iron | 0.87 (0.67–1.13) | 0.30 | 0.85 (0.62–1.17) | 0.31 |
| ACE/ARB treatment | 1.05 (0.85–1.29) | 0.66 | 1.17 (0.89–1.53) | 0.27 |
| Serum PTH (log; pg/ml) | 1.33 (1.22–1.44) | <0.001 | 1.35 (1.22–1.50) | <0.001 |
| Serum albumin (g/L) | 0.94 (0.92–0.95) | <0.001 | 0.93 (0.91– 0.95) | <0.001 |
| Serum ferritin (log; ng/ml) | – | – | 1.43 (1.26–1.61) | <0.001 |
| Time since last peritonitisa (mo) | 1.00 (0.99–1.01) | 0.998 | 1.00 (0.99–1.01) | 0.64 |
For variables with units given in parentheses, odds ratios refer to change in likelihood per unit change (e.g., an odds ratio of 0.73 indicates a 27% risk decrease per 1 L/m2 per day urine output). CI, confidence interval; ACE, angiotensin-converting enzyme; ARB, angiotensin-receptor blocker.
a
For observations in patients without previous peritonitis episodes, the study entry date minus 1 year was arbitrarily entered.