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. 2013 Feb 14;24(4):604–616. doi: 10.1681/ASN.2012050442

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Copyright © 2013 by the American Society of Nephrology

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Figure 8. — Systemic treatment with the TRPV4 activator GSK1016790A attenuates renal ARPKD manifestations. Representative kidney sections from PCK453 rats treated with vehicle and GSK1016790A for 1 month (A) and 2 months (B), respectively. (C) Summary graphs comparing relative visible cyst areas for kidney slices similar to that shown in A and B. (D) Summary graph of kidneys to total body weight ratios for PCK453 rats treated with vehicle and GSK1016790A for 1 and 2 months. *Significant decrease versus vehicle.