Table 1.
Pathways predicted to be targeted by LXA4 regulated miRNAs
| KEGG Pathway | Pathway Genesa | Predicted miRNA Targetingb | -LN (P Value)c | |||||
|---|---|---|---|---|---|---|---|---|
| let-7a | let-7c | let-7g | miR-152 | miR- 193a-5p | miR-874 | |||
| TGF-β signaling | 21 | 9 | 9 | 10 | 11 | 2 | 1 | 10.86 |
| Focal adhesion | 34 | 17 | 16 | 19 | 10 | 1 | 7 | 9.05 |
| MAPK signaling | 41 | 23 | 22 | 27 | 11 | 3 | 6 | 8.56 |
| Melanoma | 16 | 8 | 8 | 10 | 6 | 0 | 1 | 7.35 |
| Pancreatic cancer | 16 | 7 | 7 | 9 | 5 | 1 | 2 | 7.12 |
| ECM-receptor interaction | 17 | 9 | 9 | 11 | 5 | 0 | 2 | 7.01 |
| Axon guidance | 23 | 7 | 6 | 9 | 9 | 0 | 7 | 7 |
| Bladder cancer | 11 | 5 | 6 | 7 | 2 | 1 | 1 | 6.97 |
| Chronic myeloid leukemia | 16 | 8 | 8 | 10 | 5 | 0 | 2 | 6.48 |
| Cell cycle | 21 | 6 | 6 | 7 | 11 | 1 | 2 | 6.35 |
| Adherens junction | 15 | 6 | 6 | 7 | 7 | 0 | 4 | 5.95 |
| Prostate cancer | 17 | 7 | 7 | 8 | 8 | 1 | 1 | 5.52 |
| Wnt signaling | 24 | 9 | 9 | 10 | 11 | 2 | 2 | 5.15 |
| p53 signaling | 13 | 9 | 9 | 9 | 3 | 0 | 1 | 4.2 |
MAPK, mitogen-activated protein kinase; ECM, extracellular matrix.
a
Total number of genes in KEGG pathway targeted by miRNA set.
b
Number of predicted genes targeted by individual miRNAs.
c
Negative natural logarithm of the P value.