Table 3.

Associations of categories based on FGF23 and fractional excretion of phosphorus above versus below the median with mortality and CVD events

FGF23/FePi Category	Participants	Events	Model 1 HR (95% CI)	Model 2 HR (95% CI)
All-cause mortalitya
Low FGF23/low FePi	240	68	1.00 (reference)	1.00 (reference)
Low FGF23/high FePi	197	62	0.97 (0.68, 1.37)	0.99 (0.70, 1.42)
High FGF23/high FePi	239	119	1.96 (1.45, 2.66)	1.49 (1.07, 2.07)
High FGF23/low FePi	196	88	2.21 (1.60, 3.06)	1.98 (1.42, 2.77)
CVD events (MI, stroke, and CVD death)b
Low FGF23/low FePi	240	39	1.00 (reference)	1.00 (reference)
Low FGF23/high FePi	197	39	1.09 (0.69, 1.70)	1.04 (0.66, 1.63)
High FGF23/high FePi	239	66	1.69 (1.13, 2.53)	1.21 (0.78, 1.86)
High FGF23/low FePi	196	55	2.22 (1.46, 3.36)	1.92 (1.25, 2.94)

Model 1, age, sex, estrogen use (women), and race adjusted; model 2, model 1 plus diabetes, systolic BP, BMI, total cholesterol, HDL cholesterol, smoking, CRP, eGFR, ACR, and PTH.

^aP interaction FGF23 × FePi<0.001.

^bP interaction FGF23 × FePi=0.05.